FIRST BOTTLE FREE · 60-DAY MONEY-BACK GUARANTEE

You’ve felt low for months, and you don’t want to start an antidepressant to fix it.

Saffron has been tested against a placebo in 34 trials.

In a 6-week head-to-head trial, 30 mg of saffron a day worked as well as Prozac.

Your 60-day supply

60 capsules · 1 a day
Subscribe & save$59.99FREETodayFirst bottle free, ships freeDay 60Your first refill shipsThenA bottle every 2 months

60-day money-back guarantee, even if opened

No fillers or stearates. Just two ingredients.

What it does
  • Saffron slows how fast your brain clears away serotonin and dopamine.*
  • Tested on 202 adults with low mood in the biggest saffron trial so far.
Read the study
What's inside

One capsule holds 30 mg saffron extract and 220 mg glycine in a vegan capsule. The saffron is standardized to 3.5% crocin and safranal, and there are no fillers, stearates, silica or flow agents.

See the full label
How to take it

Adults take one capsule a day. Store it away from heat and moisture.

How saffron works

Saffron works on serotonin and dopamine, the same brain chemicals antidepressants target.

In 8 trials that put saffron head to head with SSRIs, it lowered depression scores about as much.

Typical saffron pillsPremium saffron pillsClean Health Lab
Standardized like the trial extractRarelyVaries3.5%crocin & safranal
Fillers or flow agentsOften (rice flour)Often (cellulose, calcium laurate)None
GuaranteeVariesVaries60 dayseven if opened
First bottle$10 to $25$45 for 30 daysFree
Tested inClinicalTrials

The guideline

31 psychiatry experts from 15 countries reviewed the evidence on saffron.

Their 2022 guideline rated saffron ‘provisionally recommended’ for depression, one of only four plant extracts it supported for depression.

49%of women on saffron saw their depression score drop by 7 points or more
26%on a placebo

86 women aged 50 to 70 with low mood and poor sleep, 28 mg a day for 12 weeks. Lopresti and Smith, Frontiers in Nutrition, 2026.

Get my first bottle free →

Day by day

Your first 60 days

In a 4-week trial of adults with low mood, people on 28 mg a day were in a better mood by the end.

  • 202adults with low mood
  • 28 mgsaffron a day
  • 12 weekssaffron or a placebo
  • 2025Journal of Nutrition
Read the study
  1. Day 1

    One capsule a day

    • 30 mg of saffron extract in each capsule
    • Take it with water
  2. Day 30

    Halfway

    • The 4-week trial ended here
  3. Day 60

    The bottle is done

    • Your first refill ships now
    • 60-day money-back guarantee, even if opened
  4. Week 12

    Into your second bottle

    • The biggest saffron trials ran 12 weeks.

Why the first bottle is free

You’ve already paid for supplements that did nothing for your mood.

So your first bottle is free. It lasts 60 days, and it can take a few weeks to know if saffron is working for you.

THE STUDY

In the biggest saffron trial so far, 202 adults with low mood took it for 12 weeks. 72 in 100 saw their depression score drop by 7 points or more, compared with 54 in 100 on a placebo.

FEWER SIDE EFFECTS

In 8 trials that compared saffron with SSRIs, about 6 fewer people in every 100 had side effects on saffron.

THE DOSE

In a 4-week trial of 128 adults with low mood, 22 mg a day did no better than a placebo, while 28 mg a day lifted their mood.

REAL SAFFRON

Studies estimate 20 to 30% of the saffron sold around the world is cut with safflower, marigold or turmeric, or colored with dye. We use an extract standardized to 3.5% crocin and safranal and test every lot for both.

1 / 4

It has just
two ingredients.

Most capsules also contain magnesium stearate or silica, which help the powder run through the machines. Ours is just the two ingredients in a vegan capsule.

30 mg

Saffron extract

From the red threads of the saffron flower, standardized to 3.5% crocin and safranal.

One small Clean Health Lab Saffron capsule beside saffron threads and the bottle
220 mg

Glycine

An amino acid your body also makes on its own.

What saffron was tested for

Mood

Women aged 50 to 70 on saffron had lower depression scores than women on a placebo.

Drive

In two trials on people taking Prozac, saffron improved arousal and erections.

Calm

In women aged 40 to 60, anxiety scores fell 33% on saffron over 12 weeks.

Serotonin

In lab studies, crocin and safranal slowed how fast brain cells clear away serotonin.

How saffron works in your brain

Saffron gets its color from crocin and its smell from safranal, and a good extract is measured by how much of those two it has.

Saffron powderStrength varies
Our extract3.5% crocin & safranal
Read the science

Crocin and safranal slow down how fast your brain clears away serotonin and dopamine, so more of both stays active between brain cells.

Here’s the full label, so you can check every amount.

We source ingredients from around the world, formulate it in Canada, and bottle and package it in the USA.

Product testingRead the certificate of analysisEvery lot is tested before it shipsAsk for your lot’s report
60 days to decide

You have 60 days to get your money back, even if the bottle is open, and returns are free.

See how returns work

Quality

We test every lot, and you can read the report for yours.

Each lot is tested for crocin and safranal, heavy metals and microbes before it ships.

  • Vegan capsule
  • No fillers
  • No stearates
  • No silica
  • No flow agents
  • Crocin & safranal tested
  • Heavy metals tested
  • Microbiology tested
  • Report for your lot
Man laughing on a sunny terrace, Clean Health Lab Saffron beside his tea

Taking it every day

  1. Start with one bottle

    Your first bottle has 60 capsules, enough for 60 days.

  2. Keep it where you’ll see it

    Put it next to something you use every morning, so you remember to take it.

  3. Give it the full 60 days

    Take it at the same time each day, whichever time you’ll remember.

60 days to decide. Even if opened. Free returns.
Clean Health Lab Saffron on a work desk in the afternoon
How is it different from an antidepressant?

Saffron is a flower extract you take as a supplement, so you don’t need a prescription. In 8 trials that compared it with SSRIs it lowered depression scores about as much, and people on saffron had fewer side effects.

What else is in the capsule?

Just 220 mg of glycine and the vegan capsule itself, and nothing else.

Is this the same as the saffron in my kitchen?

It comes from the same red threads, but kitchen saffron isn’t measured and a lot of it is cut with safflower or dyed corn silk. Ours is an extract standardized to 3.5% crocin and safranal, so every capsule has the same amount.

What should I expect, and how soon?

In the 4-week trial people were in a better mood by the end. Take it every day for the full bottle before you decide.

How do I take it?

Take one capsule a day with water. Each bottle has 60 capsules. Keep it somewhere cool and dry, and out of reach of children.

How does the two-month subscription work?

Your first bottle is free and ships free. The plan includes your first refill, which ships on day 60 for $50.99, and after that a bottle ships every two months at the same price. If you’d rather buy once, a single bottle is $59.99 plus shipping.

What if it isn’t right for me?

You have 60 days to get your money back, even if you’ve opened the bottle, and returns are free. Email or call us and we’ll help you send it back. Read the full return policy.

Clean Health Lab Saffron on a bedside table in lamplight

Saffron · 60 capsules · One a day

If you’d rather try saffron before a prescription, your first bottle is free.

Take it for the full 60 days, and if it doesn’t help, you get your money back.

The Supplement Facts

This is the panel from the bottle, and we’ll send you the testing report for your lot if you ask.

100%
Supplement Facts, ingredients and serving instructions for Clean Health Lab Saffron
Product testing

Certificate of analysis

Saffron · 30 mg

Batch 0077136

Issued by
Highland Laboratories Inc.
Report date
November 13, 2025

2 pages · 106 KB

Enter the batch number exactly as printed on your bottle.

How to read your COA

Read each result alongside its specification and test method. The method tells you how the result was established.

Ingredient amountsMeets or exceeds listed amounts · Analysis + formulation records

Saffron extract is checked for its crocin and safranal against the report’s listed specification. Glycine is recorded using formulation records (“By Input”).

An analyzed result comes from laboratory measurement. “By Input” records the ingredient added during manufacturing; it is not a separate assay.

Capsule weightWeight variances may occur.

Capsule weight and ingredient amounts are separate checks. The weight row records the capsule’s overall mass; the ingredient rows describe its contents. Read each against its own specification.

Heavy metals & microbiologyWithin the report’s listed limits.

Each heavy-metal result is below its listed maximum. Microbial counts are below their limits, and E. coli is reported negative.

The < symbol means “less than.” Compare values using the same units and serving size.

Request the COA