In a 6-week head-to-head trial, 30 mg of saffron a day worked as well as Prozac.
60-day money-back guarantee, even if opened
No fillers or stearates. It has two ingredients.
One capsule holds 30 mg saffron extract and 220 mg glycine in a vegan capsule. The saffron is standardized to 3.5% crocin and safranal, and there are no fillers, stearates, silica or flow agents.
See the full labelAdults take one capsule a day. Store it away from heat and moisture.
How saffron works
Crocin and safranal, the two compounds that give saffron its color and smell, slow how fast your brain clears away serotonin and dopamine, so more of both stays active between brain cells. In 8 trials that put saffron head to head with SSRIs, it lowered depression scores about as much, and fewer people had side effects.
Clean Health LabThe guideline
Their 2022 guideline rated saffron ‘provisionally recommended’ for depression, one of four plant extracts to earn that rating.
86 women aged 50 to 70 with low mood and poor sleep, 28 mg a day for 12 weeks. Lopresti and Smith, Frontiers in Nutrition, 2026.
Get my first bottle free →The research
Eight studies, and who ran each one.
Saffron 30 mg worked about as well as Prozac for mild to moderate depression, 6 weeks
Noorbala and Jamshidi, Tehran University of Medical Sciences
Journal of Ethnopharmacology, 2005
Read the paperDepression score fell with saffron added to an antidepressant, 8 weeks
Lopresti and Drummond, Murdoch University
Journal of Psychopharmacology, 2019
Read the paperMeaningful drop in depression score, 202 adults, 12 weeks
Lopresti and colleagues, Murdoch University
The Journal of Nutrition, 2025
Read the paperWomen 50 to 70 with low mood and poor sleep, 12 weeks
Lopresti and Smith, Murdoch University
Frontiers in Nutrition, 2026
Read the paperAdults who slept badly slept better, most of it in week one
Lopresti and Drummond, Murdoch University
Journal of Clinical Sleep Medicine, 2020
Read the paperA taskforce of 31 psychiatry experts rated saffron provisionally recommended for depression
Sarris, Berk and 29 other experts
World Journal of Biological Psychiatry, 2022
Read the paperNormal erections in men on Prozac, saffron vs placebo, 4 weeks
Modabbernia and Akhondzadeh, Tehran University of Medical Sciences
Psychopharmacology, 2012
Read the paperWomen on Prozac had better arousal, lubrication and less pain than on placebo
Kashani and Akhondzadeh, Tehran University of Medical Sciences
Human Psychopharmacology, 2013
Read the paperDay by day
The biggest saffron trial so far ran 12 weeks.
Why the first bottle is free
Your first bottle is free. It lasts 60 days, and it can take a few weeks to know if saffron is working for you.
Most capsules also contain magnesium stearate or silica, which help the powder run through the machines. Ours is just the two ingredients in a vegan capsule.
From the red threads of the saffron flower, standardized to 3.5% crocin and safranal.
An amino acid your body also makes on its own.
Both come in one vegan capsule, and you take one a day.
Women aged 50 to 70 on saffron had lower depression scores than women on a placebo.
In two trials of people taking Prozac, adding saffron improved arousal and erections.
In women aged 40 to 60, anxiety scores fell 33% on saffron over 12 weeks.
In lab studies, crocin and safranal slowed how fast brain cells clear away serotonin.
Saffron gets its color from crocin and its smell from safranal, and a good extract is measured by how much of those two it has.
Crocin and safranal slow down how fast your brain clears away serotonin and dopamine, so more of both stays active between brain cells.
The label shows every amount, and it is formulated in Canada and bottled and packaged in the USA.
You have 60 days to get your money back, even if the bottle is open, and returns are free.
See how returns workQuality
Each lot is tested for crocin and safranal, heavy metals and microbes before it ships.
Your first bottle has 60 capsules, enough for 60 days.
Put it next to something you use every morning, so you remember to take it.
Take it at the same time each day, whichever time you’ll remember.
Saffron is a flower extract you take as a supplement, so you don’t need a prescription. In 8 trials that compared it with SSRIs it lowered depression scores about as much, and people on saffron had fewer side effects.
Yes. In three trials, adults already on an antidepressant took saffron alongside it. In one, people who still felt depressed on their antidepressant added saffron for 8 weeks, and their doctor-rated depression score fell 41%, against 21% on a placebo.
Only 220 mg of glycine and the vegan capsule.
It comes from the same red threads, but kitchen saffron isn’t measured and a lot of it is cut with safflower or dyed corn silk. Ours is an extract standardized to 3.5% crocin and safranal, so every capsule has the same amount.
The saffron trials ran 4 to 12 weeks, so give the first bottle all 60 days before you decide.
Take one capsule a day with water. Each bottle has 60 capsules. Keep it somewhere cool and dry, and out of reach of children.
Your first bottle is free and ships free. The plan includes your first refill, which ships on day 60 for $55.99, and after that a bottle ships every two months at the same price. If you’d rather buy once, a single bottle is $64.99 plus shipping.
The saffron trials ran 4 to 12 weeks, and we want you to give it the full 60 days. If it isn’t right for you, you have 60 days to get your money back, even if you’ve opened the bottle.
You have 60 days to get your money back, even if you’ve opened the bottle, and returns are free. Email or call us and we’ll help you send it back. Read the full return policy.
Saffron · 60 capsules · One a day
Take it for the full 60 days, and if it doesn’t help, you get your money back.
Then $55.99 every 2 months.
60-day money-back guaranteeEven if opened. Free returns.
