Your antidepressant takes the edge off. You still feel flat.

4.9 from 2,600+ reviews

Doctors add 15 mg of L-methylfolate to an antidepressant, and this is the same form without a prescription.

~~$59.99~~ First bottle FREEClaim it →

Clean Health Lab L-Methylfolate bottle on deep green stone

Clean Health Lab L-Methylfolate beside a glass of water on a green stone counter.

Your 60-day supply

60 capsules · 1 a day

1TodayFirst bottle freeShips free

2Day 60Refill shipsEvery 2 months

3AnytimeSkip or cancelOr pause

60-day money-back guaranteeEven if opened. Free returns.

★★★★★I’m finally starting to feel like I have my energy back. Watch her routine

What it does

Folate helps your brain and nerves work normally.*
Gives your body folate in its active form, ready to use.
The same 15 mg form doctors add to an antidepressant.

Read the study

What's inside

One capsule holds 15 mg L-methylfolate (25,000 mcg DFE) and 220 mg glycine, in a vegan capsule. 60 capsules in each bottle. No fillers, stearates, silica or flow agents.

See the full label

How to take it

One capsule a day, or as directed by your healthcare professional. Store it away from heat and moisture.

Customers filmed how they take it.

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Folic acid vs. active folate

Your antidepressant works on serotonin, and your brain needs folate to make it.

The folic acid in most multivitamins has to be converted before your brain can use it, and up to 40% of people carry an MTHFR gene variant that slows that conversion down. L-methylfolate is already in the active form, so there’s nothing to convert.

Folic acidmost multivitaminsTypical methylfolate

Clean Health Lab

Ready to use

Works with MTHFR

Strength0.4 mgOften 1 mg15 mg

Guarantee–Often 30 days60 dayseven if opened

First bottle–$18 to $37Free

The folateDoctorsPrescribe

The study

Doctors add this to an antidepressant when it isn’t doing enough.

15 mg L-methylfolate is sold by prescription as a medical food. In this study, it was added for people whose antidepressant hadn’t helped enough on its own.

32%got better when 15 mg L-methylfolate was added

15%got better on a placebo

People who hadn't improved on an antidepressant alone. Papakostas et al., American Journal of Psychiatry, 2012.

Ours is the same form and the same 15 mg, and you don’t need a prescription.

Get my first bottle free →

The 60 days

What the 60 days look like

Researchers at Massachusetts General Hospital ran the trial behind the 32%.

75people on an SSRI
15 mgL-methylfolate a day
60 daysin two 30-day halves
2012American Journal of Psychiatry

Read the study

Day 1
One capsule a day
- 15 mg of active folate in each capsule
- Take it with water
“You just take one capsule a day and you’re good to go.”
@lovealwaysalyse
Day 30
Halfway
- You’re halfway through the bottle
- Keep taking one a day
Day 60
The bottle is done
- Your next bottle ships now
- 60-day money-back guarantee, even if opened
Bottle 2
Starting the second bottle
“This is my second bottle, and I’m finally starting to feel like I have my energy back.”
@eliza.cornelison

Why the first bottle is free

You’ve already paid for supplements that did nothing.

So your first bottle is free. It lasts 60 days, as long as the study ran, and we’re betting you’ll want the next one.

THE STUDY

Everyone in the study was on an antidepressant and still felt low. With 15 mg added, 32 in 100 got better. With a sugar pill, 15 in 100 did.

ONE BOTTLE

A bottle holds 60 capsules, enough for the full 60 days of the study.

YOUR GENES

Up to 4 in 10 people carry a gene that slows down how they use regular folic acid. Ours is already in the form your body uses, so that gene doesn’t get in the way.

THE DOSE

A multivitamin has 0.4 mg. Most methylfolate pills have 1 mg. Ours has 15 mg, the amount from the study.

1 / 4

It has just
two ingredients.

15 mg

L-Methylfolate

5-MTHF, the already-active form of folate.

Close-up of one Clean Health Lab capsule resting on translucent green glass

220 mg

Glycine

An amino acid your body also makes on its own.

Together in a vegan capsule. 1 capsule per serving.

Brain & nerves

Folate supports normal brain and nerve function.*

Energy metabolism

Helps your body turn food into energy.*

Methylation

Your body uses folate in methylation, a basic process inside every cell.*

Folate and your mood

Folic acid takes extra steps before your body can use it, and L-methylfolate is ready as it is.

Folic acidConversion stepsActive folate

CHL 5-MTHFAlready active

Read the science

Folate matters for normal brain function. Too little can lead to anemia, which causes tiredness and trouble concentrating.

Your MTHFR enzyme helps produce 5-MTHF, an active form of folate. Some common gene variants make that step less efficient.

CHL gives you L-methylfolate, which is already 5-MTHF, so your body doesn’t need that MTHFR step to make it.

Here’s the full label, so you can check every amount.

We source ingredients from around the world, formulate it in Canada, and bottle and package it in the USA.

Product testingRead the certificate of analysisLot 0077136 · Highland LaboratoriesView batch report

60 days to decide

60-day money-back guarantee. Even if opened. Free returns.

See how returns work

Quality

We test every lot, and you can read the report for yours.

Lot 0077136 was tested by Highland Laboratories for ingredients, heavy metals and microbiology.

Vegan capsule
No fillers
No stearates
No silica
No flow agents
Heavy metals tested
Microbiology tested
Report for your lot

Woman drinking a glass of water with Clean Health Lab L-Methylfolate on the kitchen counter

Taking it every day

Start with one bottle
A bottle has 60 capsules, and you take one a day.
Keep it where you’ll see it
Put it next to something you use every morning, so you remember to take it.
Change your refills anytime
With a subscription, your next bottle is $50.99 every two months, and you can skip, pause or cancel.

60 days to decide. Even if opened. Free returns.

Hand placing Clean Health Lab L-Methylfolate into a bag

What customers say

4.9★★★★★from 2,600+ reviews

5 ★86
4 ★13
3 ★1
2 ★0
1 ★0

The 100 reviews below

Feeling more like myself

I take an antidepressant and still had this muted, disconnected feeling. My doctor was fine with me trying L-methylfolate. I did not change my medication, and over time I started feeling more engaged with people again.

Isla G.Verified buyer

★★★★★Antidepressant support

More present on my current medication

I stayed on the same antidepressant and added L-methylfolate after speaking with my doctor. I did not feel a sudden mood jump. I noticed smaller things first. Music sounded good again, I answered texts the same day, and I stopped eating dinner in front of the TV every night. I feel present in my own life instead of just keeping it running.

Emerson J.Verified buyer

★★★★★Energy / motivation

Good so far but took time

L-methylfolate has helped me feel less drained and more willing to start things. It took close to a month for me to notice, which is why I gave it four stars instead of five.

Drew Y.Verified buyer

★★★★★Antidepressant support

A good addition for me

My antidepressant helped my mood, but I still felt flat and foggy. I talked with my prescriber before adding L-methylfolate and kept everything else the same. The first change I noticed was wanting to listen to music in the car again. Then I started replying to friends instead of letting messages sit for days. After a few weeks I felt more interested in things and more like myself.

Can I take it with my antidepressant?

Yes. Everyone in the study was already on an antidepressant, and they took 15 mg of L‑methylfolate alongside it every day for 60 days.

Is L-methylfolate different from folic acid?

Both are forms of vitamin B9. Your body has to convert folic acid before it can use it, and L-methylfolate is already the active form, 5-MTHF.

What should I expect, and how soon?

The study checked people after 60 days, so take it every day for the full bottle before you decide.

How do I take it?

Take one capsule a day with water. Each bottle has 60 capsules. Keep it somewhere cool and dry, and out of reach of children.

How does the two-month subscription work?

Your first bottle is free and ships free. After that, a new bottle ships every two months at $50.99, and you can skip, pause or cancel whenever you want. If you’d rather buy once, a single bottle is $59.99 plus shipping.

What if it isn’t right for me?

You have 60 days to get your money back, even if you’ve opened the bottle, and returns are free. Email or call us and we’ll help you send it back. Read the full return policy.

Clean Health Lab L-Methylfolate bottle and box on emerald stone

L‑Methylfolate · 60 capsules · One a day

If you still don’t feel like yourself, your first bottle is free.

Take it for the full 60 days, and if it doesn’t help, you get your money back.

Subscribe & saveFirst bottle free · Ships freeOne-time purchase$59.99 + shipping

First bottle~~Regular price $59.99~~FREEShips free

Then $50.99 every 2 months. Skip, pause or cancel.

4.9 from 2,600+ reviews

60-day money-back guaranteeEven if opened. Free returns.

Your antidepressant takes the edge off. You still feel flat.

Your meds help,
just not enough.

This folate is ready for your body to use.

Your 60-day supply

Customers filmed how they take it.

Your antidepressant works on serotonin, and your brain needs folate to make it.

Doctors add this to an antidepressant when it isn’t doing enough.

What the 60 days look like

One capsule a day

Halfway

The bottle is done

Starting the second bottle

You’ve already paid for supplements that did nothing.