Your 60-day supply
60 capsules · 1 a day1TodayFirst bottle freeShips free
2Day 60Refill shipsEvery 2 months
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60-day money-back guaranteeEven if opened. Free returns.
Your antidepressant takes the edge off. You still feel flat.
4.9 from 2,600+ reviewsDoctors add 15 mg of L-methylfolate to an antidepressant, and this is the same form without a prescription.
What it does
- Folate helps your brain and nerves work normally.*
- Gives your body folate in its active form, ready to use.
- The same 15 mg form doctors add to an antidepressant.
What's inside
One capsule holds 15 mg L-methylfolate (25,000 mcg DFE) and 220 mg glycine, in a vegan capsule. 60 capsules in each bottle. No fillers, stearates, silica or flow agents.
See the full labelHow to take it
One capsule a day, or as directed by your healthcare professional. Store it away from heat and moisture.
Customers filmed how they take it.
@eliza.cornelisonView original ↗
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Folic acid vs. active folate
Your antidepressant works on serotonin, and your brain needs folate to make it.
The folic acid in most multivitamins has to be converted before your brain can use it, and up to 40% of people carry an MTHFR gene variant that slows that conversion down. L-methylfolate is already in the active form, so there’s nothing to convert.
Folic acidmost multivitaminsTypical methylfolate
Clean Health Lab
Clean Health LabReady to use
Works with MTHFR
Strength0.4 mgOften 1 mg15 mg
Guarantee–Often 30 days60 dayseven if opened
First bottle–$18 to $37Free
The folateDoctorsPrescribe
The study
Doctors add this to an antidepressant when it isn’t doing enough.
15 mg L-methylfolate is sold by prescription as a medical food. In this study, it was added for people whose antidepressant hadn’t helped enough on its own.
32%got better when 15 mg L-methylfolate was added
15%got better on a placebo
People who hadn't improved on an antidepressant alone. Papakostas et al., American Journal of Psychiatry, 2012.
Ours is the same form and the same 15 mg, and you don’t need a prescription.
Get my first bottle free →The 60 days
What the 60 days look like
Researchers at Massachusetts General Hospital ran the trial behind the 32%.
- 75people on an SSRI
- 15 mgL-methylfolate a day
- 60 daysin two 30-day halves
- 2012American Journal of Psychiatry
- Day 1
One capsule a day
- 15 mg of active folate in each capsule
- Take it with water
“You just take one capsule a day and you’re good to go.”
@lovealwaysalyse - Day 30
Halfway
- You’re halfway through the bottle
- Keep taking one a day
- Day 60
The bottle is done
- Your next bottle ships now
- 60-day money-back guarantee, even if opened
- Bottle 2
Starting the second bottle
“This is my second bottle, and I’m finally starting to feel like I have my energy back.”
@eliza.cornelison
Why the first bottle is free
You’ve already paid for supplements that did nothing.
So your first bottle is free. It lasts 60 days, as long as the study ran, and we’re betting you’ll want the next one.
1 / 4
It has just
two ingredients.
L-Methylfolate
5-MTHF, the already-active form of folate.
Glycine
An amino acid your body also makes on its own.
Together in a vegan capsule. 1 capsule per serving.
What folate supports
Brain & nerves
Folate supports normal brain and nerve function.*
Energy metabolism
Helps your body turn food into energy.*
Methylation
Your body uses folate in methylation, a basic process inside every cell.*
Folate and your mood
Folic acid takes extra steps before your body can use it, and L-methylfolate is ready as it is.
Folic acid→Conversion steps→Active folate
CHL 5-MTHF→Already active
Read the science
Folate matters for normal brain function. Too little can lead to anemia, which causes tiredness and trouble concentrating.
Your MTHFR enzyme helps produce 5-MTHF, an active form of folate. Some common gene variants make that step less efficient.
CHL gives you L-methylfolate, which is already 5-MTHF, so your body doesn’t need that MTHFR step to make it.
Here’s the full label, so you can check every amount.
We source ingredients from around the world, formulate it in Canada, and bottle and package it in the USA.
Product testingRead the certificate of analysisLot 0077136 · Highland LaboratoriesView batch report
60 days to decide
60-day money-back guarantee. Even if opened. Free returns.
See how returns workQuality
We test every lot, and you can read the report for yours.
Lot 0077136 was tested by Highland Laboratories for ingredients, heavy metals and microbiology.
- Vegan capsule
- No fillers
- No stearates
- No silica
- No flow agents
- Heavy metals tested
- Microbiology tested
- Report for your lot
Taking it every day
Start with one bottle
A bottle has 60 capsules, and you take one a day.
Keep it where you’ll see it
Put it next to something you use every morning, so you remember to take it.
Change your refills anytime
With a subscription, your next bottle is $50.99 every two months, and you can skip, pause or cancel.
More videos from customers
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20 community videos · Swipe to meet everyone
L-Methylfolate customer reviews
4.9 from 2,600+ reviews
Featured customer review ★★★★★Exceeded My Expectations
“I was trying this for the first time and was honestly shocked by the quality. You can tell the ingredients are clean and well thought out. I’ve tried many supplements before, but this one really stands out. Definitely reordering.”
See some of whatour customers are saying.
★★★★★
Fits into an already-full morning.
“Water, breakfast, one capsule. I wanted a routine that would fit my day instead of becoming another project.”
★★★★★
One less thing to overthink.
“My supplement shelf was getting ridiculous. I wanted something I could understand without opening twelve tabs. Two listed ingredients and a simple daily routine are exactly what appealed to me.”
★★★★★
I wanted to see the details first.
“I always look for the actual label before I try something new. Having the ingredient information and batch report in the same place makes comparing my options easier.”
★★★★★
Finally understood the form.
“I had seen folate and folic acid used almost interchangeably. The explanation of already-active folate helped me understand what I was actually choosing.”
★★★★★
A simpler shelf.
“I was tired of buying complicated blends and then forgetting why I chose them. I like being able to point to the label and understand what is in this one.”
★★★★★
The routine is the easy part.
“I keep it beside the things I use every day. No scoop, no mixing, no extra drink to finish.”
★★★★★
Room to try it properly.
“I didn’t want to make a decision after two rushed mornings. A 60-day supply feels like room to settle into a consistent routine.”
★★★★★
The numbers are there to read.
“I don’t want a long list of mystery ingredients. Seeing the amounts clearly listed was one of the first things I looked for.”
★★★★★
Less guesswork before ordering.
“I checked the label, read through the formula explanation and looked at the refill details. Being able to find those answers in one visit made the decision feel less complicated.”
★★★★★
Simple without feeling skimpy.
“The formula is short, but the product information isn’t missing. I appreciate being able to keep it simple and still look deeper when I want to.”
★★★★★
Made for an ordinary day.
“I’m not looking for an elaborate wellness ritual. I want something straightforward that I can remember on busy mornings, too.”
★★★★★
The report is a useful extra.
“A clean-looking bottle only tells me so much. I like having an actual document to open and questions I can take to the brand if I need more detail.”
3 featured reviews
Is L-methylfolate different from folic acid?
Both are forms of vitamin B9. Your body has to convert folic acid before it can use it, and L-methylfolate is already the active form, 5-MTHF.
What should I expect, and how soon?
The study checked people after 60 days, so take it every day for the full bottle before you decide.
How do I take it?
Take one capsule a day with water. Each bottle has 60 capsules. Keep it somewhere cool and dry, and out of reach of children.
How does the two-month subscription work?
Your first bottle is free and ships free. After that, a new bottle ships every two months at $50.99, and you can skip, pause or cancel whenever you want. If you’d rather buy once, a single bottle is $59.99 plus shipping.
What if it isn’t right for me?
You have 60 days to get your money back, even if you’ve opened the bottle, and returns are free. Email or call us and we’ll help you send it back. Read the full return policy.
L‑Methylfolate · 60 capsules · One a day
If you still don’t feel like yourself, your first bottle is free.
Take it for the full 60 days, and if it doesn’t help, you get your money back.
First bottleRegular price $59.99FREEShips free
4.9 from 2,600+ reviewsThen $50.99 every 2 months. Skip, pause or cancel.
60-day money-back guaranteeEven if opened. Free returns.