Your 60-day supply
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Your antidepressant takes the edge off. You still feel flat.
4.9 · 2,600 five-star reviews15 mg L-methylfolate is what doctors add to an antidepressant. Same form here, no prescription.
What it does
- Supports normal brain and nerve function.*
- Gives your body folate in its active form, ready to use.
- The same 15 mg form doctors add to an antidepressant.
What's inside
One capsule holds 15 mg L-methylfolate (25,000 mcg DFE) and 220 mg glycine, in a vegan capsule. 60 capsules in each bottle. No fillers, stearates, silica or flow agents.
See the full labelHow to take it
One capsule a day, or as directed by your healthcare professional. Store it away from heat and moisture.
Their routines. Their own words.
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What you get
Folate that is ready to work from the first capsule.
Already active
5-MTHF is the form your brain uses. There is no conversion step to get through.
15 mg
The strength doctors add to an antidepressant, with no prescription needed.
Two ingredients
L-methylfolate and glycine. Every line of the label is on the page.
Tested by lot
Heavy metals and microbiology, with the report for your bottle.
Why the multivitamin didn't help
Your meds need serotonin to work with. Serotonin needs active folate.
Antidepressants work on serotonin, and your brain needs active folate to make it. The folic acid in most multivitamins has to be converted before your brain can use it, and up to 40% of people carry an MTHFR gene variant that slows that conversion down. L-methylfolate skips the step.
Folic acidmost multivitaminsTypical methylfolate
Clean Health Lab
Clean Health LabReady to use
Works with MTHFR
Strength0.4 mgOften 1 mg15 mg
Guarantee–Often 30 days60 dayseven if opened
First bottle–$18 to $37Free
The folateDoctorsPrescribe
What doctors already know
When meds only get you halfway, this is what doctors add.
15 mg L-methylfolate is sold by prescription as a medical food. Doctors add it to an antidepressant when someone isn't all the way back.
32%responded when 15 mg L-methylfolate was added
15%responded on placebo
People who hadn't improved on an antidepressant alone. Papakostas et al., American Journal of Psychiatry, 2012.
Clean Health Lab L-Methylfolate is the same active form at the same 15 mg. No prescription, and the first bottle is free.
Get my first bottle free →The 60 days
Sixty days, the way the study ran it.
The trial behind the 32% was led by researchers at Massachusetts General Hospital. Your first bottle lasts as long as the trial did.
- 75people on an SSRI
- 15 mgL-methylfolate a day
- 60 daysin two 30-day halves
- 2012American Journal of Psychiatry
- Day 1
One capsule a day
- 15 mg of active folate, ready to use
- Take it with water
- Nothing to mix, nothing to measure
“You just take one capsule a day and you’re good to go.”
@lovealwaysalyse - Day 30
Halfway
- Half the length of the study
- Half the bottle
- The same one-a-day routine
- Day 60
The full length of the study
- Your bottle is done and the next one ships
- 60-day money-back guarantee, even if opened
- Bottle 2
In a customer’s own words
“This is my second bottle, and I’m finally starting to feel like I have my energy back.”
@eliza.cornelison
Two ingredients.
Nothing to hide.
When you're already managing a prescription, the last thing you want is a supplement that’s hard to understand.
L-Methylfolate
5-MTHF, the already-active form of folate.
Glycine
A simple amino acid, clearly listed on the label.
Together in a vegan capsule. 1 capsule per serving.
What folate supports
Brain & nerves
Folate supports normal brain and nerve function.*
Energy metabolism
Supports the processes your body uses to make and use energy.*
Everyday methylation
Active folate contributes to methylation, a process involved in everyday cell function.*
When your mood feels turned down.
Give your body folate in its active form.
Folic acid→Conversion steps→Active folate
CHL 5-MTHF→Already active
The science behind the choice
Folate matters for normal brain function. Too little can lead to anemia, which may bring fatigue and difficulty concentrating.
Your MTHFR enzyme helps produce 5-MTHF, an active form of folate. Some common gene variants make that step less efficient.
CHL supplies L-methylfolate—5-MTHF directly. It bypasses that MTHFR-dependent step, supplying this form from the start.
Brain fog and tiredness can have many causes. Folate is one part of the picture.
Common MTHFR variants do not prevent people from processing folate or folic acid. These sources explain folate biology and MTHFR; they are not clinical trials of this product.
The full label. In plain sight.
Formulated in Canada. Bottled and packaged in the USA with global ingredients.
Product testingRead the certificate of analysisLot 0077136 · Highland LaboratoriesView batch report
60 days to decide
60-day money-back guarantee. Even if opened. Free returns.
See how returns workQuality
Every lot is tested. Read yours.
Lot 0077136 was tested by Highland Laboratories for ingredients, heavy metals and microbiology.
- Vegan capsule
- No fillers
- No stearates
- No silica
- No flow agents
- Heavy metals tested
- Microbiology tested
- Report for your lot
Less to juggle. One daily habit.
When the little things feel harder, keep this part simple. One capsule, paired with a habit you already have.
Start with one bottle
60 capsules. One capsule daily, or as directed by your healthcare professional.
Give it a place in your day
Pair it with a habit you already have, so it is easier to remember.
Keep your refills flexible
With a subscription, your next bottle is $50.99 every two months. Skip, pause or cancel.
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L-Methylfolate customer reviews
4.9 · 2,600 five-star reviews
Featured customer review ★★★★★Exceeded My Expectations
“I was trying this for the first time and was honestly shocked by the quality. You can tell the ingredients are clean and well thought out. I’ve tried many supplements before, but this one really stands out. Definitely reordering.”
See some of whatour customers are saying.
★★★★★
Fits into an already-full morning.
“Water, breakfast, one capsule. I wanted a routine that would fit my day instead of becoming another project.”
★★★★★
One less thing to overthink.
“My supplement shelf was getting ridiculous. I wanted something I could understand without opening twelve tabs. Two listed ingredients and a simple daily routine are exactly what appealed to me.”
★★★★★
I wanted to see the details first.
“I always look for the actual label before I try something new. Having the ingredient information and batch report in the same place makes comparing my options easier.”
★★★★★
Finally understood the form.
“I had seen folate and folic acid used almost interchangeably. The explanation of already-active folate helped me understand what I was actually choosing.”
★★★★★
A simpler shelf.
“I was tired of buying complicated blends and then forgetting why I chose them. I like being able to point to the label and understand what is in this one.”
★★★★★
The routine is the easy part.
“I keep it beside the things I use every day. No scoop, no mixing, no extra drink to finish.”
★★★★★
Room to try it properly.
“I didn’t want to make a decision after two rushed mornings. A 60-day supply feels like room to settle into a consistent routine.”
★★★★★
The numbers are there to read.
“I don’t want a long list of mystery ingredients. Seeing the amounts clearly listed was one of the first things I looked for.”
★★★★★
Less guesswork before ordering.
“I checked the label, read through the formula explanation and looked at the refill details. Being able to find those answers in one visit made the decision feel less complicated.”
★★★★★
Simple without feeling skimpy.
“The formula is short, but the product information isn’t missing. I appreciate being able to keep it simple and still look deeper when I want to.”
★★★★★
Made for an ordinary day.
“I’m not looking for an elaborate wellness ritual. I want something straightforward that I can remember on busy mornings, too.”
★★★★★
The report is a useful extra.
“A clean-looking bottle only tells me so much. I like having an actual document to open and questions I can take to the brand if I need more detail.”
3 featured reviews
Is L-methylfolate different from folic acid?
Both are forms of vitamin B9. Folic acid goes through conversion steps; L-methylfolate is already active 5-MTHF.
What should I expect—and how soon?
Folate supports normal body functions; individual needs and responses vary. There’s no guaranteed result or timeline. Brain fog, fatigue and mood changes can have many causes. Discuss persistent symptoms with your healthcare professional.
How do I take it?
The suggested routine is one capsule daily, or as directed by your healthcare professional. Each bottle contains 60 capsules. Store according to the label, away from heat and moisture, and keep out of reach of children.
How does the two-month subscription work?
Your first 60-capsule subscription bottle is free and ships free. Then it renews every two months at $50.99. You can skip, pause or cancel. The one-time option is $59.99 plus shipping.
What if it isn’t right for me?
CHL offers a 60-day money-back guarantee, including opened products, with free returns. Contact the team for help with your return. Read the full return policy.
L-Methylfolate · 60 capsules · One a day
Care for the brain you count on.
Support normal brain and nerve function with already-active folate.*
First bottleRegular price $59.99FREEShips free
4.9 · 2,600 five-star reviewsThen $50.99 every 2 months. Skip, pause or cancel.
60-day money-back guaranteeEven if opened. Free returns.